The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region.
Posts about Notch
  • Of Course Someone Made Notch's $70 Million Mansion In Minecraft

    … Minecraft creator and ex-Mojang head Markus "Notch" Persson has a new house. He spent upwards of $70 million on it, and there is a candy room. Of course there is a candy room. You will probably never have anything that nice, nor will I. But hey, we can still stroll through it in—yep—Minecraft. Dan Bovey went above and beyond the call of duty…

    Nathan Grayson/ Kotaku- 6 readers -

  • Minecraft's Creator Buys The Most Expensive House In Beverly Hills

    … In case you needed a material transaction to show you just how much money Markus Persson, aka Notch, has having sold Mojang (and Minecraft) to Microsoft, take a look at this: the dude just paid $70 million (and maybe beat out Beyonce & Jay-Z) to buy the most expensive house in Beverly Hills. The John Aaroe Group just announced the sale…

    Luke Plunkett/ Kotaku- 24 readers -
  • Mojang Officially Part of Microsoft, $2.5 Billion Buyout Completed

    … w/the Minecraft community. A day before Spencer’s announcement, Minecraft creator, Markus “Notch” Persson, departed Mojang. Tweeting about his final moments in the studio, he said: I left the mojang office for the last time, and didn’t properly say bye because everything is strange. I don’t even know what a fitting bye is. So I just left…

    Zarmena Khan/ PlayStation LifeStyle- 6 readers -
  • Minecraft in 2014: Your Guide To Mods and Modpacks

    … an eventful few years for Markus Persson, the Swedish programmer known to the world as Notch. After building a game in his bedroom, he watched as it slowly took over the world, rising to become the third best-selling videogame of all time – behind only Wii Sports and Tetris. But Minecraft in 2014 bears only a superficial resemblance to the Minecraft…

    Rock, Paper, Shotgun- 6 readers -
  • Conan O’Brien On How Minecraft Celebrate Microsoft Acquisition

    … Tweet Pin It The Minecraft universe was stunned earlier this week when news filtered through that tech giants Microsoft splashed out $2.5 billion to buy Mojang and the Minecraft franchise. So big the news, the media is doing what they do best and making light of the situation, first up talk-show host Conan O’Brien. The iconic comedian…

    LzyGmrs- 2 readers -

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